local area of diseased or damaged tissue.

Merriam-Webster Online Dictionary
lesion (noun)
- injury harm
an abnormal change in structure of an organ or part due to injury or disease , especially one that is circumscribed and well defined
lesion (Wikipedia)

A lesion is any damage or abnormal change in the tissue of an organism, usually caused by disease or trauma. Lesion is derived from the Latin laesio "injury". Lesions may occur in plants as well as animals.

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